UCB announced the results of a 6-month, randomized, double-blind, placebo-controlled clinical study, published in the journal Movement Disorders, showing that Neupro® (rotigotine transdermal system, 2 and 3 mg/24 hours) provided sustained, clinically relevant improvements in symptoms of Restless Legs Syndrome (RLS). The study also showed high rates of complete remission seen with rotigotine 2 mg or 3 mg/24 hours... (Source: Health News from Medical News Today)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Neupro® (rotigotine transdermal system) study conducted in the U.S. published in the journal Movement Disorders Study represented the longest double-blind treatment period maintained in the U.S. for the evaluation of RLS treatments High rates of ... BiopharmaceuticalsUCB, Neupro, rotigotine, Restless Legs Syndrome (Source: HSMN NewsFeed)

Neupro® (rotigotine transdermal system) study conducted in the U.S. published in the journal Movement Disorders - Study represented the longest double-blind treatment period maintained in the U.S. for the evaluation of RLS treatments - High... (Source: Drugs.com - Clinical Trials)

Neupro® (rotigotine transdermal system) study conducted in the U.S. published in the journal Movement Disorders - Study represented the longest double-blind treatment period maintained in the U.S. for the evaluation of RLS treatments - High... (Source: Drugs.com - Clinical Trials)

In this report, we analyze his clinical description and the circumstances leading to his opium addiction. © 2010 Movement Disorder Society (Source: Movement Disorders)

The dopamine system is implicated in reward-based decision making with explicit information (decision making under risk) and implicit probabilities (decision making under ambiguity). Although the pathophysiology of restless legs syndrome (RLS) is not yet fully understood, the genetic factors, iron status, and dopaminergic system are thought to play a role. RLS provides an opportunity to test the dopaminergic hypothesis in a drug-free population and to characterize reward processing using decision-making paradigms. We investigated impulsivity, impulse control disorders, and decision making in 50 untreated patients with primary RLS compared with 60 sex- and age-matched normal controls using one night of polysomnography recording, a structured psychiatric interview, and questionnaires (RLS Se...

We aimed to evaluate the frequency and determinants of restless legs syndrome (RLS) in a group of 76 patients with amyotrophic lateral sclerosis (ALS) and 100 control subjects. A diagnosis of RLS was made according to the criteria of the International RLS Study Group, and severity was assessed by the RLS severity scale. RLS was significantly more frequent in patients with ALS (ALS/RLS+) than in control subjects (25% vs. 8%; P = 0.002). Compared with control subjects, patients with ALS/RLS+ showed shorter history of RLS complaints and higher frequency of symptoms occurrence. Moreover, compared with those without RLS, patients with ALS/RLS+ showed increased functional impairment and more often reported sleep complaints. Multivariate logistic regression confirmed the association between RLS a...MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

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Content Type Journal ArticleCategory Journal ClubDOI 10.1007/s00415-010-5668-3Authors Michael Strupp, University Hospital Munich Department of Neurology and IFB (LMU) Campus Grosshadern, Marchioninistr. 15 81377 Munich Germany Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)

Abstract: A substantial literature characterizes pediatric restless legs syndrome (RLS), which occurs in about 1.9% of individuals between 8 and 18years of age. Diagnostic interview techniques and an updated inventory of pediatric RLS mimics are presented. Evidence for comorbidity of pediatric RLS with attention-deficit/hyperactivity disorder, depression, and anxiety is reviewed as is the relationship to periodic limb movements in sleep and periodic limb movement disorder. The role of relative iron deficiency in pediatric RLS is discussed, along with new data indicating the benefit of iron therapy in reducing symptoms. Five genetic variants have been linked to RLS, an important finding in a condition that is highly familial in early-onset cases. Numerous case reports and case series indica...

Abstract: This paper, intended to provide useful insights for the clinical management of sleep disturbances in attention-deficit/hyperactivity disorder (ADHD), presents a critical, updated overview of the most relevant studies on the prevalence, etiopathophysiology and treatment strategies of sleep problems associated with ADHD, including restless legs syndrome, periodic limb movements in sleep, sleep-onset delay, increased nocturnal motor activity, sleep-disordered breathing, deficit in alertness, and sleep alterations accounted for by comorbid psychiatric disorders or ADHD medications. We also discuss some possible avenues for future research in the field. (Source: Sleep Medicine)

The symptoms of restless legs syndrome sound so bizarre — creepy-crawly feelings and an uncontrollable urge to move the legs, especially at bedtime — that, until recently, many sufferers have simply not been believed. Ron Blum, 38, a Boston... (Source: OrlandoSentinel: Medical Research)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

In conclusion, we provide the first confirmation of the RLS-5 locus, and we reduce its critical region. The identification of the underlying mutation might reveal an important susceptibility gene for this common movement disorder. © 2010 Movement Disorder Society (Source: Movement Disorders)

If you have seen the movie Inception, you may be interested in learning more about the phenomenon they call "kicks". In the film, these sudden, almost startling movements are what are required to awaken the dreamer back to reality (or, in some cases, back to a higher level dream). These feelings occur commonly in sleep and are properly called night starts. There are also a few other conditions that may have arm or leg movements that should be discriminated from these, such as restless legs and periodic limb movements. In general though, this common phenomenon requires no treatment and makes for an interesting plot element in an excellent movie. Follow me on Twitter or Facebook to receive notice of all the latest updates to this site.'Kicks' in 'Inception' Movie Represent Night Starts or...

Abstract  Much evidence suggests that restless legs syndrome (RLS) is a disorder characterized by an unsuppressed response to sensory urges due to abnormalities in inhibitory pathways that specifically link sensory input and motor output. Therefore, in the present study, we tested sensory-motor integration in patients with RLS, measured by short latency afferent inhibition (SAI) and long latency afferent inhibition (LAI). SAI and LAI were determined using transcranial magnetic stimulation before and after 1month of dopaminergic treatment in RLS patients. Ten naïve patients with idiopathic RLS and ten healthy age-matched controls were recruited. Patients with secondary causes for RLS (e.g. renal failure, anaemia, low iron and ferritin) were excluded, as well as those with o...

This randomized, double-blinded, placebo-controlled trial (NCT00135993) assessed efficacy and safety of the dopamine agonist rotigotine in the treatment of idiopathic restless legs syndrome (RLS) over a 6-month maintenance period. A total of 505 eligible participants with moderate to severe RLS (IRLS sum score [ge] 15) were randomly assigned to five groups to receive either placebo or rotigotine (0.5, 1, 2, or 3 mg/24 hr) delivered by once-daily transdermal patch (fixed-dose regimen). The two co-primary efficacy parameters decreased from baseline to end of maintenance in IRLS sum score and in clinical global impressions (CGI-1) score. On both primary measures, 2 and 3 mg/24 hr rotigotine was superior to placebo (P

Ulcerative Proctitis Osteoarthritis/Rheumatoid Arthritis Restless Legs Syndrome (RLS) (Source: The Doctors Lounge - Health News)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

WASHINGTON (MedPage Today) -- The FDA warned consumers against using the malaria drug quinine sulfate (Qualaquin) for treatment of nightly leg cramps and restless legs syndrome (RLS) due to the potentially fatal side effects that off-label use may cause. (Source: MedPage Today Public Health)

Source: Food and Drug Administration Related MedlinePlus Pages: Muscle Cramps, Restless Legs (Source: MedlinePlus Health News)

Source: Food and Drug Administration Related MedlinePlus Pages: Muscle Cramps, Restless Legs (Source: MedlinePlus Health News)