NICE is currently updating existing guidance published in December 2004 on the management of anxiety. As part of this process, draft recommendations have been published on the NICE website for public consultation. The 2004 NICE guidance included the care of adults who have panic disorder (with or without agoraphobia) or generalised anxiety disorder (GAD). This update only covers the recommendations on the management of adults with a diagnosis of GAD... (Source: Health News from Medical News Today)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Conclusions: Interactions between gender and parental alcoholism were specific to certain disorders but varied in their effects, and in general female children of women with alcoholism appear at greatest risk for adult psychopathology. PMID: 20645936 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)

Source: NICE Area: News The National Institute for Health and Clinical Excellence (NICE) has issued a draft clinical practice guideline on "Generalised anxiety disorder and panic disorder (with or without agoraphobia) in adults: management in primary, secondary and community care." The guidance is a partial update of NICE clinical guideline 22 (published 2004, amended 2007). The recommendations for the treatment and management of generalised anxiety disorder have been updated. With the exception of recommendation 1.4.37, the recommendations for the treatment and management of panic disorder (with or without agoraphobia) have not been updated.   Pharmacological management has been outlined on pages 16 to 21 of the short version of the guideline.   The consultation period ...

Conclusions: Interactions between gender and parental alcoholism were specific to certain disorders but varied in their effects, and in general female children of women with alcoholism appear at greatest risk for adult psychopathology. (Source: Alcoholism: Clinical and Experimental Research)

There are connection between use of cannabis and many psychiatric disturbances in adolescents, especially "cannabis psychosis", depression, panic attacks and suicide. Negative effects could occur either as a result of a specific pharmacological effect of c... (Source: SafetyLit: All (Unduplicated))

Authors: Burkhardt SC, Wilhelm FH, Meuret AE, Blechert J, Roth WT Twenty-five panic disorder (PD) patients, 19 social phobics (SP), and 20 healthy controls (HC) sat quietly for 15min, rating their anxiety and dyspnea every 30s while respiratory, cardiovascular, and electrodermal responses were recorded. No panic attacks were reported. For self-reported anxiety and dyspnea, within-subject variability over time was higher in PD than in SP or HC. In PD within-subject correlations across 30-s epochs were significant for (a) self-reported anxiety versus dyspnea, end-tidal pCO(2), minute volume, duty cycle, skin conductance level, and interbeat interval, and for (b) dyspnea versus end-tidal pCO(2), minute volume, tidal volume, and inspiratory flow rate. Several positive or negative correlati...

I will focus on Matte Blanco's hypothesis of emotion and the unconscious as being substantially the same. This concept allows us to apply the same instruments to understanding emotional reactions as we use with manifestations of the unconscious, such as dreams and symptoms. The tendency towards undifferentiation in the deepest strata of the mind is capable of mobilizing dramatic experiences of inappropriate amplification of the concept of identity. When a simple relation of similarity is translated into equivalence, a symmetrization arises and different people or situations on a basis of a single common characteristic are treated as if identical and interchangeable. In my clinical example, Franco had a panic attack with florid somatic symptoms on the same day he felt that Sara, a woman in ...

Neuropsychobiology 2010;62:164–170 (DOI:10.1159/000318573) (Source: Karger Publishers)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Authors: K A Raczka, N Gartmann, M-L Mechias, A Reif, C Büchel, J Deckert & R Kalisch (Source: Molecular Psychiatry)

With Panic Awareness Day coming up on Saturday, Lindsay Ord spoke to a sufferer about life on the edge. (Source: IOL: Health)

Conclusions The SDS seems a reliable, valid and useful clinical tool for measuring disability in Spanish PC patients. (Source: Journal of Evaluation in Clinical Practice)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

There has long been interest in combining pharmacotherapy with psychotherapy, including cognitive behavioral therapy (CBT). More recently, basic research on fear extinction has led to interest in augmentation of CBT with the N-methyl Daspartate (NMDA) glutamate receptor partial agonist D-cycloserine (DCS) for anxiety disorders. In this article, the literature on clinical trials that have combined pharmacotherapy and CBT is briefly reviewed, focusing particularly on the anxiety disorders. The literature on CBT and DCS is then systematically reviewed. A series of randomized placebo-controlled trials on panic disorder, obsessive-compulsive disorder, social anxiety disorder, and specific phobia suggest that low dose DCS before therapy sessions may be more effective compared with CBT alone in c...

Neuropeptide S receptor gene — converging evidence for a role in panic disorder Molecular Psychiatry advance online publication, July 6, 2010. doi:10.1038/mp.2010.81 Authors: K Domschke, A Reif, H Weber, J Richter, C Hohoff, P Ohrmann, A Pedersen, J Bauer, T Suslow, H Kugel, W Heindel, C Baumann, B Klauke, C Jacob, W Maier, J Fritze, B Bandelow, P Krakowitzky, M Rothermundt, A Erhardt, E B Binder, F Holsboer, A L Gerlach, T Kircher, T Lang, G W Alpers, A Ströhle, L Fehm, A T Gloster, H-U Wittchen, V Arolt, P Pauli, A Hamm & J Deckert (Source: Molecular Psychiatry)

Conclusions. While paroxetine was superior to placebo, aerobic exercise did not differ from relaxation training in most efficacy measures. PMID: 20602575 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)

Conclusions: These results emphasize gender as an important variable in neural activation patterns of emotional processing and may help to further elucidate the biological substrate of gender-specific susceptibility for PD. Depression and Anxiety 0:1-10, 2010. © 2010 Wiley-Liss, Inc. (Source: Depression and Anxiety)

Conclusions: This study provides support for the effectiveness of Internet CBT in a psychiatric setting for patients with panic disorder, and suggests that it is equally effective as the more widely used group administered CBT in reducing panic- and agoraphobic symptoms, as well as being more cost effective with respect to therapist time.Trial registrationClinicalTrials.gov NCT00845260 (Source: BMC Psychiatry - Latest articles)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Conclusions: CR-2526 is a promising potential clinical candidate for the effective treatment of nausea/emesis induced by a broad spectrum of emetic challenges in a wide range of clinical indications without undesired side effects of sedation, anxiety, or induction of panic attacks. Based on pre-clinical data, anticipatory nausea also may be a clinical target. CR-2526 appears to act through 5-HT1A agonism and through a newly identified receptor in the final common central pathway for nausea/emesis. The compound could provide effective treatment for inadequately controlled nausea/emesis and potentially replace the multi-pharmacology often required in multiple clinical settings. The compound is on a pre-IND path with plans to execute a phase I/II study in humans.Support: Cenomed, Inc. sponsor...

Conclusions. Our results support the hypothesis of an aberrant processing of sensory information in PD patients. This phenomenon may underlie an enhanced responsiveness to anxiety-relevant or irrelevant stimuli possibly increasing PD vulnerability. PMID: 20586534 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)

OBJECTIVE: US-based studies have suggested that panic attacks (PA) are common and associated with an increased prevalence of mental disorders and poorer quality of life, and may be a marker of severe psychopathology. Using a population-based survey with a ... (Source: SafetyLit: All (Unduplicated))

In this study, participants were randomized to either unassisted bibliotherapy (n=20) with a scheduled follow-up telephone interview or to a waiting list control group (n=19). Following a structured psychiatric interview, participants in the treatment group were sent a self-help book consisting of 10 chapters based on cognitive behavioral strategies for the treatment of panic disorder. No therapist contact of any kind was provided during the treatment phase, which lasted for 10 weeks. Results showed that the treatment group had, in comparison to the control group, improved on all outcome measures at posttreatment and at 3-month follow-up. The tentative conclusion drawn from these results is that pure bibliotherapy with a clear deadline can be effective for people suffering from panic disor...