Opioid receptors mediate the physiologic effects of morphine, which allows patients to tolerate otherwise debilitating pain, but chronic exposure to morphine results in diminished analgesia. Gupta et al. have explored … [Read more] (Source: Editors' Choice)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Archaeology: Tracing the Ancient Glass Trade | Psychology: Notes from Underground | Pharmacology: Partners in Pain Prevention | Physics: Squeezing Fermi Gases into Two Dimensions | Evolution: Growing Closer Together | Chemistry: Watching Rings Cycle | Neuroscience: Splicing Misdirects Migrants (Source: Science: Current Issue)

A recent study provides the first direct evidence of linkage between elevated intrinsic (resting-state) brain connectivity and spontaneous pain intensity in patients with fibromyalgia. This research shows an interaction of multiple brain networks, offering greater understanding of how pain arises. (Source: ScienceDaily Headlines)

Conclusions: Khat consumption decreases pain threshold and affects patients’ comfort during local anesthesia and during surgery in routine cataract surgery. Patients consuming Khat need more care during local anesthesia to make the surgery comfortable. (Source: Medical Science Monitor)

Conclusions: This study suggests that HGF may be a novel, highly efficacious agent in the minimization of intra-abdominal adhesion. Although further studies are needed to assess the mechanisms of HGF in neutralizing the effect of TGF-beta1, these findings also provide a cellular and molecular basis for the action of HGF as an anti-adhesion agent. (Source: Medical Science Monitor)

BOSTON - A former member of Pfizer Inc.'s speakers' bureau who pleaded guilty earlier this year to falsifying data in support of a published study on Pfizer's Celebrex was sentenced to six months in prison on June 25 in Massachusetts federal court (United States of America v. Scott Reuben, No. 10-30002, D. Mass.; See February 2010, Page 5). Full story on lexis.com (Source: LexisNexis® Mealey's™ Arthritis Drugs Legal News)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Cosmetic surgeons can be very skilled in their trade and achieve excellent aesthetic outcomes, but those who can minimize the discomfort and pain that a patient perceives during and after a cosmetic procedure are likely to be the most professionally — and financially — successful. (Source: Modern Medicine)

(Wiley-Blackwell) A recent study from Australian researchers determined that transforaminal injection of steroids was a viable alternative to surgery for lumbar radicular pain due to disc herniation. Full details of the study appear in the August issue of Pain Medicine, a journal published by Wiley-Blackwell on behalf of the American Academy of Pain Medicine, the Faculty of Pain Medicine of the Australian and New Zealand College of Anaesthetists, and the International Spine Intervention Society. (Source: EurekAlert! - Medicine and Health)

Do you want to have a sense of meaning and purpose?  Do you want to feel a sense of pride in what you do and accomplish?  Then finding a career you can thrive in is going to be a key piece of the puzzle for your personal growth and development.Work spares us from three vices: Boredom, Vice, and Need.  --Voltaire           I am indebted to both Temple Grandin, PhD, and to author Rudy Simone for the ideas on which this article is based.  Dr. Grandin is probably well known to you as a professor who is diagnosed with Autism.  Rudy Simone is self identified as an Aspie, and has recently written a book called Asperger's On the Job.Getting StartedIt's important to be honest with yourself about your intellectual capabi...

CONCLUSIONS: Continuous dynamic traction with a dynamic external fixator compares favorably with the use of static external fixators for the treatment of unstable fractures of the distal part of the radius. LEVEL OF EVIDENCE: Therapeutic Level I. See Instructions to Authors for a complete description of levels of evidence. PMID: 20660231 [PubMed - in process] (Source: The Journal of Bone and Joint Surgery. American volume)

CONCLUSIONS: The postmortem findings of osteolysis and/or lymphocytic infiltration associated with eight clinically well-functioning, low wear devices (a total wear rate of MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

(Source: BMJ Online First)

Conclusion: Acupuncture, when compared with trigger point injection, combined with cyclobenzaprine chlorhydrate and sodium dipyrone provided similar pain relief and improvement in quality of life measures at 4 weeks. ▪ (Source: Pain Practice)

Chronic physical comorbidity is common in dementia. However, there is an absence of evidence to support good practice guidelines for attention to these problems. We aimed to study the extent of this comorbidity and its impact on cognitive function and disability in population-based studies in low and middle income countries, where chronic diseases and impairments are likely to be both common and undertreated.A multicentre cross-sectional survey of all over 65 year old residents (n = 15 022) in 11 catchment areas in China, India, Cuba, Dominican Republic, Venezuela, Mexico and Peru. We estimated the prevalence of pain, incontinence, hearing and visual impairments, mobility impairment and undernutrition according to the presence of dementia and its severity, and, among those with dementia, t...

Conclusion. Although the development of total hip replacement surgery has been very successful, there are issues that need to be addressed in relation to postoperative pain management. The findings in this study show that there are reasons for making a more concerted effort to develop postoperative pain management, particularly during the first few days after surgery.Relevance to clinical practice. The results provide some indication that pain management for this group of patients in the early postoperative period needs to be improved to reduce the fear of moving and improve the process of regaining independence. Devoting more attention to the patients during the initial postoperative phase may be the key to improve the training and making it even more effective. (Source: Journal of Clinic...

We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male. The patient initially experienced intermittent abdominal pain, and radiographic workup revealed an encapsulated retroperitoneal mass. A laparotomy was performed and the resected specimen represented a cystic lesion, the inner surface of which was mostly covered by sebaceous debris with hairs. Microscopically, mature derivatives of all three germ layers as well as completely developed gastrointestinal tract were identified. Adenocarcinoma without stromal invasion was observed adjacent to the small intestinal mucosa. Immunohistochemistry of the adenocarcinoma tissue revealed p53 overexpression and high Ki-67 labeling index as well as positive staining for CD10, cytokera...MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Hurd T, Chadwick P, Cote J, Cockwill J, Mole TR, Smith JM. Impact of gauze-based NPWT on the patient and nursing experience in the treatment of challenging wounds. Negative pressure wound therapy is widely used in the treatment of hard-to-heal wounds; however, pain during dressing changes, which is often associated with pain on the commencement and cessation of pressure application and because of in-growth of new granulation tissue into interstices of foam dressings, is often experienced. Anecdotal reports have suggested that choice of gauze as the negative pressure wound therapy dressing may reduce the pain associated with dressing changes. A prospective, multi-center, non-comparative clinical investigation was carried out using gauze-based negative pressure wound therapy in chronic and a...

Company now offers pain specialists the most comprehensive portfolio of SCS percutaneous leads NATICK, Mass., July 29 (HSMN NewsFeed) -- Boston Scientific Corporation (NYSE:BSX ) today announced U.S. Food and Drug Administration approval of two spina... Devices, Neurology, FDABoston Scientific, Precision Plus, Spinal Cord Stimulator, Neuromodulation (Source: HSMN NewsFeed)

Conclusion We observed palliated pain and improved well-being for patients on this trial. However, these improvements were similar in both treatment arms, suggesting that the addition of cetuximab did not contribute to improvement in these HRQL outcomes. (Source: Journal of Clinical Oncology)

Authors: Soper DE Pelvic inflammatory disease (PID) is an infection-caused inflammatory continuum from the cervix to the peritoneal cavity. Most importantly, it is associated with fallopian tube inflammation, which can lead to infertility, ectopic pregnancy, and chronic pelvic pain. The microbial etiology is linked to sexually transmitted microorganisms, including Chlamydia trachomatis, Neisseria gonorrheae, Mycoplasma genitalium, and bacterial vaginosis-associated microorganisms, predominantly anaerobes. Pelvic pain and fever are commonly absent in women with confirmed PID. Clinicians should consider milder symptoms such as abnormal vaginal discharge, metrorrhagia, postcoital bleeding, and urinary frequency as potential symptoms associated with the disease, particularly in women at ri...