Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early-stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty-four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow ...MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Thyroid eye disease (TED) is the most common cause of proptosis in adults, and should always be a consideration in patients with unexplained diplopia, pain, or optic nerve dysfunction. At least 80% of TED is associated with Graves disease (GD), and at least 50% of patients with GD develop clinically evident symptomatic TED. The most confusing patients for doctors of all subspecialties are the patients with eye symptoms and signs that precede serum evidence of a thyroid imbalance. Management of TED may include immunosuppressive medications, radiation, or surgery. Although the prognosis for optic nerve function is excellent, the restrictive dysmotility can result in permanent disability. Orbit and eyelid reconstruction are reserved for stable, inactive patients and are the final steps in min...

Conclusions: Anastomotic stricture, secondary to the surgical treatment of esophageal atresia, remains a frequent complication in patients with esophageal atresia. Esophageal dilation with Savary-Gilliard bougies is a safe and effective procedure in the management of strictures. (Source: Journal of Pediatric Surgery)

Conclusion  We present herein the clinical, neuroimaging, and molecular findings of a patient with MNGIE caused by a novel homozygous TYMP gene mutation (c.112G>T which convert codon 38 from glutamate to a stop codon [p.38E>X]). Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00431-010-1237-0Authors Zeren Barış, Gazi University Hospital Pediatric Gastroenterology Ankara TurkeyTuba Eminoğlu, Gazi University Hospital Pediatric Metabolism and Nutrition Ankara TurkeyBuket Dalgıç, Gazi University Hospital Pediatric Gastroenterology Ankara TurkeyLeyla Tümer, Gazi University Hospital Pediatric Metabolism and Nutrition Ankara TurkeyAlev Hasanoğlu, Gazi University Hospital Pediatric Metabolism and Nutrition Ankara Turkey Journal European Jou...

Authors: Camilleri M PMID: 20410880 [PubMed - indexed for MEDLINE] (Source: Clinical Pharmacology and Therapeutics)

Lindberg G, Tornblom H, Iwarzon M, et al. (Department of Medicine, Division of Gastroenterology and Hepatology, Karolinska University Hospital, Huddinge, Stockholm, Sweden). Full-thickness biopsy findings in chronic intestinal pseudo-obstruction and enteric dysmotility. Gut 2009;58:1084–1090. (Source: Gastroenterology)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Conclusion: Autoantibodies against GnRH can be detected independently on treatment of GnRH analogue. Whether the generation of the antibody is directly linked to neuron degeneration and chronic gastrointestinal symptoms in patients with intestinal dysmotility, remains to be answered. (Source: BMC Gastroenterology)

Conclusion: Autoantibodies against GnRH can be detected independently on treatment of GnRH analogue. Whether the generation of the antibody is directly linked to neuron degeneration and chronic gastrointestinal symptoms in patients with intestinal dysmotility, remains to be answered. (Source: BMC Gastroenterology)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Gallbladder diseases, particularly gallstone-related syndromes, are common clinical problems facing practicing gastroenterologists and surgeons. Our understanding of the pathogenesis of gallbladder disease, including gallstones, acalculous cholecystitis, gallbladder dysmotility, and gallbladder cancer, continues to advance at a rapid pace. Furthermore, our ability to diagnose and treat gallbladder diseases is rapidly evolving. (Source: Gastroenterology Clinics of North America)

Gallbladder diseases, particularly gallstone-related syndromes, are common clinical problems facing practicing gastroenterologists and surgeons. Our understanding of the pathogenesis of gallbladder disease, including gallstones, acalculous cholecystitis, gallbladder dysmotility, and gallbladder cancer, continues to advance at a rapid pace. Furthermore, our ability to diagnose and treat gallbladder diseases is rapidly evolving. (Source: Gastroenterology Clinics of North America)

Abstract  Fabry disease is an inherited disorder of lipid metabolism caused by deficient activity of the lysosomal enzyme α-galactosidase A. Burning peripheral pain with triggered crises of excruciating pain and gastrointestinal dysmotility point to Fabry small fiber neuropathy; angiokeratoma, corneal deposits, and hypohidrosis are other common early manifestations. Progressive dysfunction of the kidneys, heart, and/or brain develops in adulthood. Diagnosis is often delayed which is of great concern, as therapeutic outcomes with enzyme replacement therapy are generally more favorable in early stages of Fabry disease. Results of a survey among 360 rheumatologists and pediatricians clinically managing patients with rheumatologic conditions demonstrate that Fabry manifestatio...

Abstract  Fabry disease is an inherited disorder of lipid metabolism caused by deficient activity of the lysosomal enzyme α-galactosidase A. Burning peripheral pain with triggered crises of excruciating pain and gastrointestinal dysmotility point to Fabry small fiber neuropathy; angiokeratoma, corneal deposits, and hypohidrosis are other common early manifestations. Progressive dysfunction of the kidneys, heart, and/or brain develops in adulthood. Diagnosis is often delayed which is of great concern, as therapeutic outcomes with enzyme replacement therapy are generally more favorable in early stages of Fabry disease. Results of a survey among 360 rheumatologists and pediatricians clinically managing patients with rheumatologic conditions demonstrate that Fabry manifestatio...

The esophagus is susceptible to the effects of opiates, something to keep in mind when a patient on opiates presents with dysphagia Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)

The esophagus is susceptible to the effects of opiates, something to keep in mind when a patient on opiates presents with dysphagia Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)

In conclusion, here we described that donor-derived BMDCs might differentiate into gastrointestinal ICCs after radiation injury, which provided an alternative source for the origin of the ICCs in the muscular plexus of adult intestine. These results further identified the plasticity of BMDCs and indicated therapeutic implications of BMDCs for the gastrointestinal dysmotility caused by ICCs disorders. (Source: Journal of Biomedicine and Biotechnology)

In conclusion, here we described that donor-derived BMDCs might differentiate into gastrointestinal ICCs after radiation injury, which provided an alternative source for the origin of the ICCs in the muscular plexus of adult intestine. These results further identified the plasticity of BMDCs and indicated therapeutic implications of BMDCs for the gastrointestinal dysmotility caused by ICCs disorders. (Source: Journal of Biomedicine and Biotechnology)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.