Conclusion: Children with Down syndrome had smaller oral cavities, and smaller vocal tract volumes. No significant differences were found for pharyngeal length, pharyngeal volume, and vocal tract length between these two groups. (Source: International Journal of Pediatric Otorhinolaryngology)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

In conclusion, Down syndrome was found to be an independent parameter associated with a significantly higher risk for mortality in the early postoperative period after Fontan surgery. (Source: The American Journal of Cardiology)

QPR's team for children with Down's syndrome (Source: BBC News | Health | UK Edition)

Scand J Caring Sci; 2010;'Have you had the test?' A discourse analysis of media presentation of prenatal screening in Iceland Nuchal translucency (NT) screening has come to be widely used in antenatal care in many countries. In the capital area of Iceland, which is the focus of this study, 84% of pregnant women underwent screening in 2005. At the time no official policy had been formulated regarding the use of this screening, and very limited public discussion had taken place on the ethical issues related to its use. Although screening has been widely welcomed as a scientific and technological improvement, it may also have unintended consequences, both for practitioners and prospective parents, and for particular groups such as the disabled, which have not been fully explored. The purpose ...

Conclusion Women from ethnic minority groups less often made an informed decision whether or not to participate in prenatal screening. Interventions to decrease these ethnic differences should first of all be aimed at overcoming language barriers and increasing comprehension among women with a low education level. To further develop diversity-sensitive strategies for counselling, it should be investigated how women from different ethnic backgrounds value informed decision-making in prenatal screening, what decision-relevant knowledge they need and what they take into account when considering participation in prenatal screening. (Source: Journal of Epidemiology and Community Health)

CONCLUSION : THI leads to a small but significant reduction of the NT measurement and this could reduce the sensitivity of the screening for Down syndrome. Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 20205154 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Persons with Down's syndrome usually have great problems with memory; this being precisely one of the characteristics which differentiates them from other people. Particularly notable is the poor capacity they have for retaining information received orally, but also that concerning visual-spatial memory should be taken into account. This topic has hardly been dealt with to date and Mr Azkona decided to take up the challenge. Starting with this differential phenomenon, he has little by little unravelled the problem until he came up with the DYRK1A gene... (Source: Health News from Medical News Today)

Persons with Down's syndrome usually have great problems with memory; this being precisely one of the characteristics which differentiates them from other people. Particularly notable is the poor capacity they have for retaining information received orally, but also that concerning visual-spatial memory should be taken into account... (Source: Genetics News From Medical News Today)

Research undertaken in recent years on Down's syndrome has focused on the DYRK1A gene. The superexpression of this gene affects transmission in the neurones, according to Mr Garikoitz Azkona. In his PhD thesis, The molecular bases of neuropathology in Down's syndrome: the role of DYRK1A, Mr Azkona argues that this failure in neurone transmission could be behind the problem that persons with Down's syndrome have regarding visual-spatial memory... (Source: Health News from Medical News Today)

Between 5 and 10 percent of babies with Down syndrome develop a transient form of leukemia that usually resolves on its own. However, for reasons that haven't been clear, 20 to 30 percent of these babies progress to a more serious leukemia known as Down syndrome acute megakaryoblastic leukemia (DS-AMKL), which affects the blood progenitor cells that form red blood cells and platelets. Now, researchers at Children's Hospital Boston have found a gene regulator they believe to be a key player in DS-AMKL, advancing understanding of how the disease develops and how to treat it... (Source: Health News from Medical News Today)

Between 5 and 10 percent of babies with Down syndrome develop a transient form of leukemia that usually resolves on its own. However, for reasons that haven't been clear, 20 to 30 percent of these babies progress to a more serious leukemia known as Down syndrome acute megakaryoblastic leukemia (DS-AMKL), which affects the blood progenitor cells that form red blood cells and platelets... (Source: Lymphoma / Leukemia News From Medical News Today)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Research undertaken in recent years on Down's syndrome has focused on the DYRK1A gene. The superexpression of this gene affects transmission in the neurones, according to Mr Garikoitz Azkona... (Source: Pediatrics News From Medical News Today)

Conclusions These studies suggest that the Hebb effect is essentially preserved within Down syndrome, implying that explicit verbal short-term memory is dissociable from potentially more implicit Hebb learning. The relative strength in receptive vocabulary observed in Down syndrome may therefore be supported by largely intact long-term as opposed to short-term serial order learning. This in turn may have implications for teaching methods and interventions that present new phonological material to individuals with Down syndrome. (Source: Journal of Intellectual Disability Research)

The life expectancy of adults with Down syndrome has increased dramatically over the last 30 years, leading to increasing numbers of adults with Down syndrome now living into middle and old age. Early-onset dementia of the Alzheimer type is highly prevalent in adults with Down syndrome in the sixth decade, and this has overshadowed other important conditions related to aging among adults with Down syndrome. The authors' aim was to update and summarize current knowledge on these conditions, and examine causes of morbidity and mortality in older people with Down syndrome by conducting a systematic review of the published literature for the period: 1993[ndash]2008. They reviewed English-language literature drawn from searches in the electronic databases Medline, CINAHL, and PsycINFO, as well ...

(Source: Journal of Policy and Practice in Intellectual Disabilities)

Research undertaken in recent years on Down syndrome has focused on the DYRK1A gene. The super-expression of this gene affects transmission in the neurons, according to a new study. (Source: ScienceDaily Headlines)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Key player found for a cancer typical in Down syndrome - Over-expression of gene regulator spurs development of leukemia in babies with Down syndrome. (Source: Disabled World)

Children with trisomy 21/Down syndrome (DS) are at high risk to develop acute megakaryoblastic leukemia (DS-AMKL) and the related transient leukemia (DS-TL). The factors on human chromosome 21 (Hsa21) that confer this predisposing effect, especially in synergy with consistently mutated transcription factor GATA1 (GATA1s), remain poorly understood. Here, we investigated the role of Hsa21-encoded miR-125b-2, a microRNA (miRNA) overexpressed in DS-AMKL/TL, in hematopoiesis and leukemogenesis. We identified a function of miR-125b-2 in increasing proliferation and self-renewal of human and mouse megakaryocytic progenitors (MPs) and megakaryocytic/erythroid progenitors (MEPs). miR-125b-2 overexpression did not affect megakaryocytic and erythroid differentiation, but severely perturbed myeloid di...

(Children's Hospital Boston) Between five and 10 percent of babies with Down syndrome develop a transient form of leukemia that usually resolves on its own. However, for reasons that haven't been clear, 20-30 percent of these babies progress to a more serious leukemia known as Down syndrome acute megakaryoblastic leukemia, which affects the blood progenitor cells that form red blood cells and platelets. (Source: EurekAlert! - Medicine and Health)

(Elhuyar Fundazioa) Research undertaken in recent years on Down syndrome has focused on the DYRK1A gene. The super-expression of this gene affects transmission in the neurons, according to Garikoitz Azkona. (Source: EurekAlert! - Social and Behavioral Science)