CONCLUSION: Environmental, cognitive and behavioral factors related to feeding were significantly present among the subjects of the study, putting deglutition at risk. Other specific deglutition difficulties were also identified. Managing these difficulties is important, in order to avoid health complications for elderly women. (Source: Revista da Sociedade Brasileira de Fonoaudiologia)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Dement Geriatr Cogn Disord 2010;30:39–42 (DOI:10.1159/000315509) (Source: Dementia and Geriatric Cognitive Disorders)

Dement Geriatr Cogn Disord 2010;30:51–56 (DOI:10.1159/000314875) (Source: Dementia and Geriatric Cognitive Disorders)

In this study, we examined mRNA and protein expression, as well as biological activity of NEP, IDE, and ECE-1 in human frontal cortex by real-time RT-PCR for mRNA, immunoblotting for protein, and highly sensitive and specific fluorescence assays for activity. The relationships between A[beta]-degrading enzymes and pathologic measures and clinical features were also assessed. The results showed that NEP mRNA, protein level, and activity were decreased in AD compared with normal controls with no cognitive impairment (NCI). In contrast, IDE activity was unchanged, but there was higher expression of IDE mRNA, indicating a possible compensatory reaction because of deficits in activity. ECE-1 expression in AD brain showed no significant difference compared with age-matched controls. Correlation ...

Authors: Buée L, Troquier L, Burnouf S, Belarbi K, Van der Jeugd A, Ahmed T, Fernandez-Gomez F, Caillierez R, Grosjean ME, Begard S, Barbot B, Demeyer D, Obriot H, Brion I, Buée-Scherrer V, Maurage CA, Balschun D, D'hooge R, Hamdane M, Blum D, Sergeant N Tau pathology is characterized by intracellular aggregates of abnormally and hyperphosphorylated tau proteins. It is encountered in many neurodegenerative disorders, but also in aging. These neurodegenerative disorders are referred to as tauopathies. Comparative biochemistry of the tau aggregates shows that they differ in both tau isoform phosphorylation and content, which enables a molecular classification of tauopathies. In conditions of dementia, NFD (neurofibrillary degeneration) severity is correlated to cognitive impairment...

People who experience rapid eye movement sleep behaviour disorder (RBD) may go on to develop conditions such as dementia with Lewy bodies, Parkinson's disease, or multiple system atrophy. The researchers studied the medical records of 27 people with these three neurodegenerative conditions who had also experienced RBD earlier in life. Thestudy, published in the online issue of Neurology, found that 63% of people who experienced RBD developed dementia with Lewy bodies or Parkinson's disease in later life... (Source: Health News from Medical News Today)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

ROCHESTER, N.Y., July 29 (UPI) -- A sleep disorder may signal dementia or Parkinson's disease up to 50 years before diagnosis, U.S. researchers said. Parkinson's disease - Dementia - Sleep disorder - Health - Conditions and Diseases (Source: Health News - UPI.com)

Background: Alzheimer's disease (AD) and cerebrovascular disease (CVD) including chronic small vessel disease of the brain (SVD) are the most frequent causes of dementia. AD is associated with metabolism of amyloid precursor protein (APP) and low levels of amyloid-beta peptide (Abeta) X-42 in the cerebrospinal fluid (CSF). CVD and SVD are established risk factors for AD, brain white matter lesions (WML) are established surrogate markers for SVD and are also associated with reduced CSF AbetaX-42.A cohort survey was performed to examine whether SVD or acute CVD affects APP metabolism and to explore a potential association between WML and APP metabolism in two groups; cognitively impaired patients, subjective and mild (SCI and MCI) and stroke patients. Through measurements of CSF APP metaboli...

Source: NICE Area: Evidence > Guidelines NICE quality standards contain quality statements describing key markers of high-quality, cost-effective care for a particular clinical condition or pathway. These statements may focus on prevention, as well as elements of health and social care, and will promote an integrated approach to improving quality. Although these standards are not requirements or targets, the care system is obliged to have regard to them in planning and delivering services, as part of a general duty to secure continuous improvement in quality.   This quality standard focuses on dementia - the following statements are given for this topic: 1. People with dementia receive care from staff appropriately trained in dementia care. 2. People with suspected dementia a...MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Dement Geriatr Cogn Disord 2010;30:43–50 (DOI:10.1159/000314681) (Source: Karger Publishers)

Chronic physical comorbidity is common in dementia. However, there is an absence of evidence to support good practice guidelines for attention to these problems. We aimed to study the extent of this comorbidity and its impact on cognitive function and disability in population-based studies in low and middle income countries, where chronic diseases and impairments are likely to be both common and undertreated.A multicentre cross-sectional survey of all over 65 year old residents (n = 15 022) in 11 catchment areas in China, India, Cuba, Dominican Republic, Venezuela, Mexico and Peru. We estimated the prevalence of pain, incontinence, hearing and visual impairments, mobility impairment and undernutrition according to the presence of dementia and its severity, and, among those with dementia, t...

'Behind the headlines' provides an unbiased and evidence-based analysis of health stories that make the news. (Source: Neurological Conditions Specialist Library)

Systematic review of the evidence for an association of white matter hyperintensities with risk of stroke, cognitive decline, dementia, and death. (Source: Neurological Conditions Specialist Library)

'Behind the headlines' provides an unbiased and evidence-based analysis of health stories that make the news. (Source: Neurological Conditions Specialist Library)

The objective of this paper is to assess the association between delirium in elderly patients and long-term poor outcome, defined as mortality, institutionalization, or dementia, while controlling for important confounders. (Source: Neurological Conditions Specialist Library)

American neurologists and sleep experts suggest in a recent study that rapid eye movement (REM) sleep behavior disorder could be an early sign of Parkinson's disease or dementia that develops up to 50 years later. You can read how neurologist and sleep specialist Dr Bradley F. Boeve and colleagues from the Mayo Clinic College of Medicine, Rochester, Minnesota arrived at their findings in an online before print issue of a paper published in the journal Neurology on 28 July... (Source: Health News from Medical News Today)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Conclusion These findings suggest that the brain changes associated with certain neurodegenerative diseases could begin many years before the symptoms start to show. There are a few points to note about this study: This study was not set up to evaluate the strength of the association between RBD and neurodegenerative disease, and it does not shed any light on how many people with restless sleep go on to develop neurological conditions. The study only looked at a few specific types of dementia and not the more common Alzheimer’s or vascular type of dementia. As such, these findings are even less applicable to people concerned about the more common dementias. These participants had a very specific form of severe sleep disturbance, involving lashing out and characteristic brain wav...

Attempts to treat the world's most common form of dementia may have been attacking its symptoms, not its root cause (Source: New Scientist - Health)

Attempts to treat the world's most common form of dementia may have been attacking its symptoms, not its root cause (Source: New Scientist - Health)

Researchers found a link between people with rapid eye movement sleep behaviour disorders and brain conditions many years later. (Source: the Mail online | Health)