This study presents preliminary results of an open clinical trial of a day program for adolescents with AN.Participants were 26 anorectic females, 12-18 years, who completed the "Transition Program."Significant change emerged on measures of weight gain, and behavioral and attitudinal measures of eating pathology. Large effect sizes were evident for weight gain at 6 month follow-up. Preliminary trends suggest that treatment gains on these and other measures of eating pathology were maintained at 6 month follow-up.Preliminary results support day program treatment for adolescents with mild-moderately severe eating disorders. Present outcomes are discussed with respect to the dearth of efficacious treatment options for adolescents. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2010) (So...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

To examine resting awake EEG in adolescent AN participants before and after refeeding to determine if EEG abnormalities in Anorexia Nervosa (AN) are reversible.In 37 adolescent first admission AN patients and 45 healthy controls, EEG was recorded during short duration "eyes open" and "eyes closed" awake resting conditions. Repeat testing occurred in 28 AN participants after refeeding and subsequent weight gain.In "eyes open," underweight AN participants exhibit reduced relative alpha power and increased beta power in frontal brain regions. A significant increase in alpha, and decrease in beta and delta power was observed within participants after refeeding. In "eyes closed", underweight AN participants had elevated theta in parietal-occipital regions which remained after refeeding.EEG abno...

We present the UCAN treatment for patients with AN and their partners and discuss important considerations in the delivery of the intervention.With further evaluation, we expect that UCAN will emerge to be an effective, acceptable, disseminable, and developmentally tailored intervention that will serve to improve both core AN pathology as well as couple functioning. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2010) (Source: International Journal of Eating Disorders)

Conclusions: These findings indicate almost complete normalization of emotion recognition ability as well as the restoration of eToM in recovered patients, despite the observation of difficulties in both domains in currently ill patients. Findings suggest that similarities between AN and ASD in poor eToM are restricted to the currently ill AN state and such difficulties in AN may be a factor of starvation. (Source: Psychosomatic Medicine)

Conclusion  The mechanisms underlying bone loss in AN patients remain unclear and complex, involving hypoestrogenia as well as nutritional factors such as insulin-like growth factor and leptin. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1120-xAuthors I. Legroux-Gérot, University of Lille II Department of Rheumatology 59037 Lille Cédex FranceJ. Vignau, University of Lille II Department of Addictology 59037 Lille Cédex FranceE. Biver, University of Lille II Department of Rheumatology 59037 Lille Cédex FranceP. Pigny, University of Lille II Department of Biology 59037 Lille Cédex FranceF. Collier, University of Lille II Department of Gynaecology 59037 Lille Cédex FranceX. Marchandise, University of Lille II Department of Nuclear Medic...

A 57-year-old man presented to the emergency department with painful purple discoloration of three toes on his left foot. He had also had intermittent blurry vision, intermittent chest pain, fatigue, anorexia, drenching night sweats, and a weight loss of 7 kg (15 lb) over the previous 3 weeks. His roommate commented that the patient had been slightly confused. (Source: New England Journal of Medicine)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

CONCLUSIONS: Subthreshold presentations in women with lifetime AN and BN were common, resembled the initial diagnosis, and were associated with modest improvements in psychosocial functioning. For most with lifetime AN and BN, subthreshold presentations seem to represent part of the course of illness and to fit within the original AN or BN diagnosis. PMID: 20047706 [PubMed - as supplied by publisher] (Source: Psychological Medicine)

Conclusion  Weekly paclitaxel administration shows activity against advanced gastric cancer also in the third-line setting. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0524-9Authors Rai Shimoyama, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanHirofumi Yasui, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanNarikazu Boku, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanYusuke Onozawa, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanShuichi Hironaka, Shizuoka Cancer...

We examined this three-drug combination in children with relapsed solid tumors. Patients received orally administered irinotecan together with temozolomide and vincristine on two different schedules, using cefixime to reduce irinotecan-associated diarrhea.Oral irinotecan was given daily on days 1-5 and 8-12 (Schedule A), or on days 1-5 (Schedule B). Temozolomide was given on days 1-5, with vincristine 1.5 mg/m2 administered on days 1 and 8 (Schedule A) or day 1 (Schedule B) in 21-day courses.On Schedule A, the maximum tolerated dose of oral irinotecan was 35 mg/m2/day combined with temozolomide 100 mg/m2/day and vincristine on days 1 and 8. Dose-limiting toxicities in 4 of 12 patients included hepatotoxicity, abdominal pain, anorexia, hypokalemia, and thrombocytopenia at 50 mg/m2/day. Usin...

My boyfriend and I have just come back from a night in London with friends, a couple like us. I've got on so splendidly well with them in the past, but this time everything felt subtly different, and food was mostly to blame, I think.I felt a first twinge of discomfort when, as he set about preparing the lunch, she said to him that she didn't want anything - then, to me, that she'd had ‘quite a big breakfast' so wasn't hungry. In fact, as he laid out the spread of salads and cold meats and chicken curry, she decided either that she was hungry after all, or that she'd be polite and join in, and she took a couple of small helpings of salad. Neither of them had any of the bread and butter, bought specially for us, it seemed; he was for a long time overweight, and lost weight by a low-carb r...

Several maladaptive eating behaviors, beyond anorexia, can affect women. Indeed, some 10 to 15 percent of women have maladaptive eating behaviours and attitudes according to new study from the Université de Montréal and the Douglas Mental Health University Institute published in the International Journal of Eating Disorders. "Our results are disquieting," says Lise Gauvin, a professor at the Université de Montréal Department of Social and Preventive Medicine. "Women are exposed to many contradictory messages... (Source: Health News from Medical News Today)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Several maladaptive eating behaviors, beyond anorexia, can affect women. Indeed, some 10 to 15 percent of women have maladaptive eating behaviours and attitudes according to new study from the Université de Montréal and the Douglas Mental Health University Institute published in the International Journal of Eating Disorders... (Source: Women's Health / OBGYN News From Medical News Today)

Tooth resorption (TR) is a common dental disorder that affects up to two-thirds of older cats. It can produce anorexia, excessive salivation, personality changes, and other signs of oral pain. Resorption of the tooth is characterized by subgingival, odontoclastic destruction of apparently healthy teeth. Odontoclasts progressively erode away the tooth resulting in eventual loss of the tooth from continued resorption or a fracture of a damaged tooth. Cats with TR commonly have multiple teeth affected. (Source: Advances in Small Animal Medicine and Surgery)

Copper-associated chronic hepatitis (CACH) is a recently recognized disease of Labrador retrievers. The average age of Labrador retrievers with CACH is 7 years with a range of 2.5 to 10.5 years. Female dogs are predisposed to the disease. Clinical signs in affected dogs are non-specific, such as anorexia, vomiting, and weight loss. Typical laboratory findings include increased serum alanine aminotransferase activity that is increased disproportionately to alkaline phosphatase activity. Histopathologic characteristics are centrolobular localization of copper and the association of copper accumulation with the hepatic lesions. (Source: Advances in Small Animal Medicine and Surgery)

This is the second Christmas I've had as an adult, eating. It's been lovely and slightly stressful by turns. I find it funny how the normality that I have achieved, just eating with my boyfriend or with my colleagues or with friends, every day, has now been turned into something of a novelty, even while remaining still completely normal. With so many people - thirteen for the day itself, nine left now - and being in my mother's house, there's the inevitable cumulative tension of meal after meal en masse, with all the rich plethora of food that Christmas is about - this lunchtime someone thought it a good idea to make fried potato cakes, and someone else wanted salad, and I was heating soup, and suddenly there were about five cooks in the kitchen, and the potato cake-frying went on for the ...

A disruption of the circadian timing system, as identified by monitoring of marker biorhythms, is common in cancer patients. The recording of the rest—activity rhythm with a wrist actigraph has been commonly used. This noninvasive monitoring allows a robust estimation of circadian disruption. The authors have previously found that altered patterns of circadian rest—activity rhythms are significantly and independently associated with the severity of fatigue and anorexia in patients with metastatic colorectal cancer. Elevated proinflammatory cytokines could partly account for this circadian disruption and its associated constitutional symptoms. Here, the authors present and discuss the data supporting the hypothesis that circadian disruption is often associated with fatigue and a...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

According to the principle of patient autonomy, patients have the right to be self-determining in decisions about their own medical care, which includes the right to refuse treatment. However, a treatment refusal may legitimately be overridden in cases where the decision is judged to be incompetent. It has recently been proposed that in assessments of competence, attention should be paid to the evaluative judgments that guide patients' treatment decisions. In this paper I examine this claim in light of theories of practical rationality, focusing on the difficult case of an anorexic person who is judged to be competent and refuses treatment, thereby putting themselves at risk of serious harm. I argue that the standard criteria for competence assess whether a treatment decision satisfies the...

Conclusions  DCS combination chemotherapy is highly active against unresectable metastatic gastric cancer and can be given safely with proper management of adverse events. Further studies of this combination are warranted. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1215-2Authors Yasushi Sato, Sapporo Medical University Fourth Department of Internal Medicine, School of Medicine South 1 West 16, Chuo-ku Sapporo 060-8543 JapanTetsuji Takayama, Tokushima University Department of Gastroenterology and Oncology Tokushima JapanTamotsu Sagawa, Sapporo Medical University Fourth Department of Internal Medicine, School of Medicine South 1 West 16, Chuo-ku Sapporo 060-8543 JapanYasuo Takahashi, Hokkaido Cancer Center Department of Gastroenterology Sa...

Conclusions: Our results prompt for the recognition of co-morbid EDs among bipolar patients, indicating that BED, along with other EDs, may influence in different ways both clinical characteristics and course of the illness. Further perspective studies are necessary to better define the relationships between different EDs and Bipolar Spectrum disorders. (Source: Journal of Affective Disorders)

Authors: Mello GW, Oliveira DM, Carvalho CJ, Cavalcante MV, Costa FA, Riet-Correa F, Silva SM Farmers report that the pods of Luetzelburgia auriculata cause digestive signs and death when ingested by goats. To demonstrate the toxicity of the pods of this plant 12 goats were divided into 4 groups of 3 goats each. Groups 1, 2, 3 and 4 were administered 2.5, 1, 0.5 and nil g of pods per kg body weight, respectively. Goats in Groups 1 and 2 developed decreased ruminal movements followed by anorexia, depression and soft feces or diarrhea. Goats in Group 1 died 59-106 hours after first showing clinical signs. Goats in Group 2 also regurgitated rumen content, but all recovered 65-90 hours after first showing clinical signs. The only clinical sign shown by goats in Group 3 was regurgitation of...